Fzd1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comFzd1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Fzd1(Gene name) > Rat

Fzd1 (Gene name),

Frizzled-1 (Protein name ), FZD1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fzd1;

Protein name:

Frizzled-1(Fz-1;rFz1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

N/A

Function:

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.

Subcellular Location:

Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

641

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

641:

YLMTLIVGIT | SGFWIWSGKT | LNSWRKFYTR | LTNSKQGETT | V

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q08463

UniGene:

Rn.6575

Pfam:

PF01534

SMR:

Q08463

STRING:

10116.ENSRNOP00000021979

Uniprot:

Q08463

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ELISA Kit for Rat Fz-1

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ELISA Kit for Rat Fz-1

Cat.:

E11110m

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Packing:

96T

ELISA Kit for Rat Fz-1

Cat.:

E11110r

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96T

ELISA Kit for Rat Fz-1

Cat.:

E11110h

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Manual:

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96T

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CLIA Kit for Rat Fz-1

Cat.:

U11110h

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96T

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CLIA Kit for Rat Fz-1

Cat.:

U11110r

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Packing:

96T

CLIA Kit for Rat Fz-1

Cat.:

U11110m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Fz-1

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Polyclonal Antibody for Rat Fz-1

Cat.:

P11110Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Fz-1

Protein for Rat Fz-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues."
Chan S.D.H. , Karpf D.B. , Fowlkes M.E. , Hooks M. , Bradley M.S. , Vuong V. , Bambino T. , Liu M.Y.C. , Arnaud C.D. , Strewler G.J. , Nissenson R.A.
J. Biol. Chem.267:25202-25207(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Osteosarcoma.
2.

"Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner."
Sheldahl L.C. , Park M. , Malbon C.C. , Moon R.T.
Curr. Biol.9:695-698(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COUPLING TO BETA-CATENIN PATHWAY

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